Is fenfluramine-phentermine therapy associated with valvular heart disease?
Fenfluramine-phentermine therapy raises significant safety concerns regarding the development of valvular heart disease and pulmonary hypertension.
These cases arouse concern that fenfluramine-phentermine therapy may be associated with valvular heart disease. Candidates for fenfluramine-phentermine therapy should be informed about serious potential adverse effects, including pulmonary hypertension and valvular heart disease.
Connolly et al. (1997) studied this question.