Are intraoperative hypotension and cumulative norepinephrine dose associated with postoperative acute kidney injury in adults undergoing noncardiac surgery?
Intraoperative hypotension and high cumulative norepinephrine doses are independently associated with postoperative acute kidney injury in noncardiac surgery.
Both intraoperative hypotension and cumulative intraoperative norepinephrine dose were independently associated with postoperative AKI in patients undergoing noncardiac surgery. Pending results of trials testing whether these relationships are causal, it seems prudent to avoid both profound hypotension and high norepinephrine doses in adults undergoing noncardiac surgery.
Saugel et al. (2024) studied this question.
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