Are insulin resistance-related indices associated with the incidence and progression of cardiometabolic multimorbidity?
Insulin resistance indices, specifically TyG-WHtR and TyG-WC, may serve as valuable markers for predicting the progression of cardiometabolic multimorbidity and identifying high-risk individuals for targeted interventions.
Our findings highlight the critical role of IR-related indices, particularly TyG-WHtR and TyG-WC, in the incidence, progression, and prevention of CMM. The mediation effects of biomarkers indicate the potential for targeted interventions to reduce CMM risk in high-IR individuals.
Tian et al. (2025) studied this question.