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September 2, 2017Circulation267 citationsOpen Access

Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease

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AGAnkur GuptaVTViviany R. TaquetiTHTim P. van de Hoef

Key Points

  • To determine the comparative and integrated prognostic value of coronary flow reserve and maximal myocardial blood flow for predicting cardiovascular mortality in patients with stable coronary artery disease.
  • Assessed coronary circulatory function noninvasively by measuring coronary flow reserve (CFR) and maximal myocardial blood flow (MBF) in patients with known or suspected coronary artery disease.

Structured PICO

Does the integration of coronary flow reserve (CFR) and maximal myocardial blood flow (MBF) predict cardiovascular mortality in patients with stable coronary artery disease?

P
Population
Patients with known or suspected stable coronary artery disease
I
Intervention
Integrated noninvasive physiological assessment of coronary circulatory function (coronary flow reserve [CFR] and maximal myocardial blood flow [MBF])
O
Outcome
Cardiovascular mortalityhard clinical

Integrating coronary flow reserve and maximal myocardial blood flow provides unique prognostic phenotypes for predicting cardiovascular mortality in patients with stable coronary artery disease.

Abstract

CFR is a stronger predictor of cardiovascular mortality than maximal MBF. Concordant and discordant categories based on integrating CFR and maximal MBF identify unique prognostic phenotypes of patients with known or suspected coronary artery disease.

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Cite This Study

Gupta et al. (2017) studied this question.

synapsesocial.com/papers/69d73bb7c74376700bf30e16https://doi.org/10.1161/circulationaha.117.029992
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