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June 11, 2018SHILAP Revista de lepidopterología497 citationsOpen Access

Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy

AGAmber GilesMHMarsha-Kay HutchinsonHSHeather M. Sonnemann

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Abstract

Dexamethasone-mediated T cell suppression diminishes naïve T cell proliferation and differentiation by attenuating the CD28 co-stimulatory pathway. However, CTLA-4, but not PD-1 blockade can partially prevent some of the inhibitory effects of dexamethasone on the immune response.

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Giles et al. (2018) studied this question.

synapsesocial.com/papers/69d74c4e66db266bcd48f39dhttps://doi.org/10.1186/s40425-018-0371-5
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