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January 21, 2003Circulation542 citationsOpen Access

Effect of Erythropoietin on Exercise Capacity in Patients With Moderate to Severe Chronic Heart Failure

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DMDonna ManciniSKStuart D. KatzCLChim C. Lang

Key Points

  • To evaluate the impact of erythropoietin administration on exercise performance and physiological oxygen transport in patients with moderate to severe chronic heart failure.
  • Assessed exercise tolerance and peak oxygen uptake (VO2) in patients diagnosed with moderate to severe chronic heart failure.

Structured PICO

Does erythropoietin improve exercise capacity in patients with moderate to severe chronic heart failure?

P
Population
Patients with moderate to severe chronic heart failure (CHF)
I
Intervention
Erythropoietin (EPO)
O
Outcome
Exercise capacitysurrogate

Erythropoietin improves exercise capacity in patients with moderate to severe chronic heart failure by increasing hemoglobin concentration and oxygen delivery.

Abstract

EPO significantly enhances exercise capacity in patients with CHF. One mechanism of improvement in VO2 is increased oxygen delivery from increased hemoglobin concentration.

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Cite This Study

Mancini et al. (2003) studied this question.

synapsesocial.com/papers/69d752645f9a1dad5348fc52https://doi.org/10.1161/01.cir.0000044914.42696.6a
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