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March 27, 2002Organic Letters254 citations

Brønsted Acid-Catalyzed Intramolecular Hydroamination of Protected Alkenylamines. Synthesis of Pyrrolidines and Piperidines

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BSB. SchlummerJHJohn F. Hartwig

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Abstract

reaction: see text. The cyclization of aminoalkenes bearing an electron-withdrawing group on the nitrogen atom was catalyzed by triflic or sulfuric acid in toluene. Pyrrolidines and piperidines were formed in excellent yields. N-phenylanilides also underwent cyclization to form gamma-lactams.

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Schlummer et al. (2002) studied this question.

synapsesocial.com/papers/69d75b62ef4aa71f97f30e66https://doi.org/10.1021/ol025659j
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