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April 16, 2002Circulation743 citationsOpen Access

Multimarker Approach to Risk Stratification in Non-ST Elevation Acute Coronary Syndromes

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MSMarc S. SabatineDMDavid A. MorrowJLJames A. de Lemos

Structured PICO

Does a multimarker strategy using Troponin, CRP, and BNP improve risk stratification for major cardiac events in patients with Non-ST Elevation Acute Coronary Syndromes?

P
Population
Patients with Non-ST Elevation Acute Coronary Syndromes (NSTE-ACS)
I
Intervention
Multimarker risk stratification strategy categorizing patients based on the number of elevated biomarkers at presentation (Troponin, CRP, and BNP)
O
Outcome
Short- and long-term major cardiac eventscomposite

Combining Troponin, CRP, and BNP into a simple multimarker strategy provides effective short- and long-term risk stratification for patients with NSTE-ACS.

Abstract

Troponin, CRP, and BNP each provide unique prognostic information in patients with ACS. A simple multimarker strategy that categorizes patients based on the number of elevated biomarkers at presentation allows risk stratification over a broad range of short- and long-term major cardiac events.

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Sabatine et al. (2002) studied this question.

synapsesocial.com/papers/69d76004b6e34cdcae48f4a9https://doi.org/10.1161/01.cir.0000015464.18023.0a
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