To create a comprehensive software tool and database that integrates large-scale ChIP-X experiments to infer transcription factor regulatory interactions.
Curated and integrated genome-wide transcription factor binding data from ChIP-seq, ChIP-chip, and related high-throughput profiling experiments.
Developed a web-based computational tool (ChEA) to analyze user-submitted gene sets for transcription factor enrichment.
Constructed a freely available web database linking numerous transcription factors to their downstream target genes across mammalian systems.
Provided an interactive platform allowing researchers to identify upstream transcription factors controlling experimental gene expression profiles.
Abstract
The ChEA software and ChIP-X database is freely available online at: http://amp.pharm.mssm.edu/lib/chea.jsp.