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January 1, 2011Chemical Society Reviews1,481 citations

Decarboxylative coupling reactions: a modern strategy for C–C-bond formation

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NRNuria RodríguezLGLukas J. Gooßen

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Abstract

This critical review examines transition metal-catalyzed decarboxylative couplings that have emerged within recent years as a powerful strategy to form carbon-carbon or carbon-heteroatom bonds starting from carboxylic acids. In these reactions, C-C bonds to carboxylate groups are cleaved, and in their place, new carbon-carbon bonds are formed. Decarboxylative cross-couplings constitute advantageous alternatives to traditional cross-coupling or addition reactions involving preformed organometallic reagents. Decarboxylative reaction variants are also known for Heck reactions, direct arylation processes, and carbon-heteroatom bond forming reactions.

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Rodríguez et al. (2011) studied this question.

synapsesocial.com/papers/69d76e6d447a5ff6a2b8a734https://doi.org/10.1039/c1cs15093f
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