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March 29, 2023Journal of Clinical Oncology356 citations

Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

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CLCornelia LiedtkeCMChafika MazouniKHKenneth R. Hess

Key Points

  • To evaluate the relationship between response to neoadjuvant chemotherapy and long-term survival in patients with triple-negative breast cancer compared to non-triple-negative subtypes.
  • Evaluated pathologic complete response (pCR) and residual disease (RD) following neoadjuvant chemotherapy.
  • Compared survival outcomes between patients with triple-negative breast cancer (TNBC) and non-TNBC.
  • Patients with TNBC achieve higher rates of pCR compared with non-TNBC, and those achieving pCR experience excellent survival.
  • Patients with TNBC who have residual disease after neoadjuvant chemotherapy experience significantly worse survival than non-TNBC patients, especially during the first 3 years.

Abstract

Patients with TNBC have increased pCR rates compared with non-TNBC, and those with pCR have excellent survival. However, patients with RD after neoadjuvant chemotherapy have significantly worse survival if they have TNBC compared with non-TNBC, particularly in the first 3 years.

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Cite This Study

Liedtke et al. (2023) studied this question.

synapsesocial.com/papers/69d77ebcef4aa71f97f317c4https://doi.org/10.1200/jco.22.02572
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer2008 · 2,931 citations
  2. 2Triple-Negative Breast Cancer: Predictive Factors for Pathological Complete Response and Prognostic Impact of Clinical, Pathological, and Radiological Parameters2026
  3. 3Clinicopathological Predictors of Pathologic Complete Response in Triple-Negative Breast Cancer: Impact of Platinum-Based Neoadjuvant Chemotherapy2026
  4. 4CLINICAL AND PROGNOSTIC SIGNIFICANCE OF PATHOLOGICAL COMPLETE RESPONSE FOLLOWING CONTEMPORARY NEOADJUVANT THERAPY IN TRIPLE NEGATIVE BREAST CANCER: A PROSPECTIVE OBSERVATIONAL STUDY2026
  5. 5Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Systematic Review of Breast and Node Pathologic Response2026 · 3 citations