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January 13, 2009Angewandte Chemie International Edition1,296 citationsOpen Access

Nanomedicine—Challenge and Perspectives

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KRKristina RiehemannSSStefan W. SchneiderTLThomas A. Luger

Key Points

  • To provide an overview of recent developments, technological capabilities, and emerging challenges across the cross-disciplinary field of nanomedicine.
  • Narrative review synthesizing molecular-scale characterization techniques, chemical surface engineering, and biomedical applications.
  • Evaluation of nanoscale diagnostic tools, therapeutic strategies, and associated safety and ethical considerations.
  • Local probes and molecular imaging enable high-resolution characterization of nanoscale surface and interface properties at precise anatomical targets.
  • Chemical modification of nanomaterial surfaces facilitates targeted drug delivery, enhanced biocompatibility, and integration with neuroprosthetic devices.
  • Clinical adoption remains constrained by critical safety concerns regarding nanomaterial toxicity and broader ethical implications.

Abstract

The application of nanotechnology concepts to medicine joins two large cross-disciplinary fields with an unprecedented societal and economical potential arising from the natural combination of specific achievements in the respective fields. The common basis evolves from the molecular-scale properties relevant to the two fields. Local probes and molecular imaging techniques allow surface and interface properties to be characterized on a nanometer scale at predefined locations, while chemical approaches offer the opportunity to elaborate and address surfaces, for example, for targeted drug delivery, enhanced biocompatibility, and neuroprosthetic purposes. However, concerns arise in this cross-disciplinary area about toxicological aspects and ethical implications. This Review gives an overview of selected recent developments and applications of nanomedicine.

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Cite This Study

Riehemann et al. (2009) studied this question.

synapsesocial.com/papers/69d787d2db9d5e1bf4b8b451https://doi.org/10.1002/anie.200802585
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