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May 30, 2022Nature Methods10,049 citationsOpen Access

ColabFold: making protein folding accessible to all

MMMilot MirditaSeoul National UniversityKSKonstantin SchützeLudwig-Maximilians-Universität MünchenYMYoshitaka MoriwakiTokyo Medical and Dental University

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Abstract

ColabFold offers accelerated prediction of protein structures and complexes by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold's 40-60-fold faster search and optimized model utilization enables prediction of close to 1,000 structures per day on a server with one graphics processing unit. Coupled with Google Colaboratory, ColabFold becomes a free and accessible platform for protein folding. ColabFold is open-source software available at https://github.com/sokrypton/ColabFold and its novel environmental databases are available at https://colabfold.mmseqs.com .

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Mirdita et al. (2022) studied this question.

synapsesocial.com/papers/69d78d82d84d071b73f307a1https://doi.org/10.1038/s41592-022-01488-1
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