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November 5, 2021JNCI Journal of the National Cancer Institute358 citationsOpen Access

The Incidence of Breast Cancer Recurrence 10-32 Years After Primary Diagnosis

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RPRikke Nørgaard PedersenBEBuket Öztürk EsenLMLene Mellemkjær

Key Points

  • Evaluate the long-term incidence of breast cancer recurrence and identify risk factors associated with disease return 10 to 32 years after primary diagnosis.
  • Tracked long-term breast cancer recurrence rates extending from 10 up to 32 years post-primary diagnosis.
  • Assessed patient and tumor characteristics, including tumor size, lymph node burden, and estrogen receptor status, as predictors of late recurrence.
  • Breast cancer recurrences continue to occur up to 32 years following primary diagnosis.
  • Risk of late recurrence is elevated in patients presenting with high lymph node burden, large tumor size, and estrogen receptor-positive disease.

Abstract

Recurrences continued to occur up to 32 years after primary diagnosis. Women with high lymph node burden, large tumor size, and estrogen receptor-positive tumors had increased risk of late recurrence. Such patients may warrant extended surveillance, more aggressive treatment, or new therapy approaches.

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Cite This Study

Pedersen et al. (2021) studied this question.

synapsesocial.com/papers/69d7af6eb1cb92dd1bb8bb1bhttps://doi.org/10.1093/jnci/djab202
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