Does the triglyceride-glucose index (TyG) mediate the association between body mass index and stroke risk in middle-aged and older Chinese adults?
The triglyceride-glucose index mediates over 50% of the association between BMI and stroke, highlighting insulin resistance as a key pathway in obesity-related stroke risk.
TyG appeared to be associated with stroke risk and mediates more than 50% of the total association between BMI and stroke in middle-aged and older Chinese adults. Public health efforts aiming at the reduction of body weight might decrease the stroke risk due to insulin resistance and the burden of stroke.
Huo et al. (2024) studied this question.