Does endothelium-restricted human preproET-1 overexpression cause structural remodeling and endothelial dysfunction in a murine model?
Endothelium-restricted overexpression of human ET-1 in a new murine model directly causes vascular remodeling and endothelial dysfunction, partly via NAD(P)H oxidase activation.
In this new murine model of endothelium-restricted human preproET-1 overexpression, ET-1 caused structural remodeling and endothelial dysfunction of resistance vessels, consistent with a direct nonhemodynamic effect of ET-1 on the vasculature, at least in part through the activation of vascular NAD(P)H oxidase.
Amiri et al. (2004) studied this question.