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February 28, 2025SHILAP Revista de lepidopterología22 citationsOpen Access

BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2

BXBu-tuo XuSWShengrong WanQWQi Wu

Structured PICO

P
Population
Diabetic cardiomyopathy (DbCM) models
I
Intervention
BDH1 overexpression
O
Outcome
Amelioration of diabetic cardiomyopathy

BDH1 overexpression may offer a novel therapeutic approach for diabetic cardiomyopathy by epigenetically regulating LCN2.

Abstract

Our results uncovered a novel mechanism whereby myocardial BDH1 ameliorates DbCM via epigenetic regulation of LCN2, which highlights the potential of BDH1/LCN2-based therapeutics in DbCM.

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69d81f8e8c03fbaff8bedd63https://doi.org/10.1186/s12933-025-02646-3
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