Does activation of mitophagy protect against high fat diet-induced diabetic cardiomyopathy?
Mitophagy plays a critical protective role against high fat diet-induced diabetic cardiomyopathy by preventing mitochondrial dysfunction and lipid accumulation.
Mitophagy serves as an essential quality control mechanism for mitochondria in the heart during HFD consumption. Impairment of mitophagy induces mitochondrial dysfunction and lipid accumulation, thereby exacerbating diabetic cardiomyopathy. Conversely, activation of mitophagy protects against HFD-induced diabetic cardiomyopathy.
Tong et al. (2019) studied this question.