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October 26, 1991BMJ2,741 citationsOpen Access

Fetal and infant growth and impaired glucose tolerance at age 64.

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CHC. N. HalesDBDavid J. BarkerPCP. Clark

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Abstract

Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes. Reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction. Reduced intrauterine growth is linked with high blood pressure, which may explain the association between hypertension and impaired glucose tolerance.

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Cite This Study

Hales et al. (1991) studied this question.

synapsesocial.com/papers/69d83b0105ee2ba81dbef469https://doi.org/10.1136/bmj.303.6809.1019
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