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April 1, 1963The Journal of Cell Biology25,092 citationsOpen Access

THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

EREdward S. Reynolds

Key Points

  • Evaluate the efficacy of high-pH lead citrate solutions as electron-opaque staining agents for biological specimens in electron microscopy.
  • Formulated aqueous solutions of lead salts stabilized at high pH for ultrathin section staining.
  • Applied high-pH lead citrate to biological tissue sections prepared for transmission electron microscopy.
  • High-pH lead citrate acts as a stable and potent electron-opaque stain for biological samples.
  • Lead staining markedly enhances the electron scattering and ultrastructural contrast of cellular components and organelles.

Abstract

Aqueous solutions of lead salts (1, 2) and saturated

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Cite This Study

Edward S. Reynolds (1963) studied this question.

synapsesocial.com/papers/69d845e0d56ca42147d17fe7https://doi.org/10.1083/jcb.17.1.208
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Staining of Tissue Sections for Electron Microscopy with Heavy Metals1958 · 4,142 citations
  2. 2SIMPLE METHODS FOR "STAINING WITH LEAD" AT HIGH pH IN ELECTRON MICROSCOPY1961 · 1,469 citations
  3. 3A Method of staining Sectioned Tissues with Lead for Electron Microscopy1960 · 34 citations
  4. 4A TECHNIQUE FOR THE SIMULTANEOUS DIRT-FREE LEAD STAINING OF SEVERAL ELECTRON MICROSCOPE GRIDS OF THIN SECTIONS1960 · 27 citations
  5. 5Treatise on inorganic chemistry1956 · 257 citations