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April 10, 2026SHILAP Revista de lepidopterologíaOpen Access

Yiqi Huoxue Yangyin Decoction attenuates diabetic nephropathy in db/db mice by modulating METTL3-mediated m6A methylation of mTOR to restore podocyte autophagy

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Authors

JHJinXing HeWNWendi NiuJQJiahui Qian

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Overview

A traditional Chinese medicine formula improves kidney function by restoring autophagy in diabetic nephropathy.

Key Points

  • The research aims to understand how Yiqi Huoxue Yangyin Decoction affects podocyte autophagy and diabetic nephropathy.
  • Characterization of YHY's chemical profile using UPLC-MS/MS.
  • Evaluation in a db/db mouse model for diabetic nephropathy.
  • Assessment of renal function, podocyte injury markers, and autophagy flux.
  • Analysis of the METTL3-m6A-mTOR pathway activity.
  • YHY treatment improved renal dysfunction and reduced podocyte injury in mice.
  • The study found impaired autophagy and active mTOR signaling in diabetic models.
  • YHY treatment decreased METTL3 expression and m6A methylation levels, enhancing autophagy.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/69d892886c1944d70ce03edfhttps://doi.org/10.3389/fphar.2026.1783423
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