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April 10, 2026Annals of African Medicine0 citations

Clinical Utility of Using Hematological Markers of Systemic Inflammation as Surrogate Markers for Glycated Hemoglobin in Resource-limited Settings – A Prospective Observational Study

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VVVeena VarierAAArjun AsokPWPrasanth C. B. Warrier

Key Points

  • To evaluate the association between hematological markers of systemic inflammation and glycated hemoglobin levels.
  • Prospective observational design
  • Assessment of various hematological parameters
  • Identification of associations with glycated hemoglobin
  • Establishment of a specific NLR cutoff value
  • Hematological parameters were significantly associated with HbA1c levels.
  • An NLR cutoff of 1.79 indicated suboptimal glycemic control.
  • NLR may serve as an effective marker for identifying glycemic control in resource-limited settings.

Abstract

The study concluded that a set of haematological parameters (NLR, PLR, absolute neutrophil count, absolute monocyte count, platelet count, systemic inflammatory response index, and systemic immune-inflammation index) is a significant associate of HbA1c and a potential surrogate marker for glycaemic control. The study also concluded that an NLR cutoff of 1.79 may be used as the value above which glycaemic control is suboptimal. In resource-limited settings, NLR may serve as a pragmatic adjunct marker for identifying suboptimal glycaemic control.

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Cite This Study

Varier et al. (2026) studied this question.

synapsesocial.com/papers/69d893626c1944d70ce046c1https://doi.org/10.4103/aam.aam_845_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of HbA1c levels with neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with diabetes mellitus: a case–control study2026 · 1 citations
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  3. 3Neutrophil-to-Lymphocyte Ratio as a Potential Biomarker to Managing Type 2 Diabetes Mellitus and Predicting Disease Progression2024 · 5 citations
  4. 4Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte ratios as inflammatory biomarkers in Type-2 Diabetes Mellitus: Across-sectional study in Maiduguri, Nigeria2025
  5. 5A Study of Relationships between the HbA1c Level and Inflammatory Markers, Neutrophil-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Controlled and Uncontrolled Type 2 Diabetes Mellitus2024 · 7 citations