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April 10, 2026Stereotactic and Functional Neurosurgery0 citations

Gamma Knife Pituitary Radiosurgery for Refractory Metastatic Bone Pain: A Single-Centre Retrospective Palliative Case Series

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SWSoon Kuen WongBSBeehong SoonUniversity Kebangsaan Malaysia Medical CentreFFFarizal FadzilUniversiti Sains Malaysia

Key Points

  • This research aims to evaluate the effectiveness of gamma knife radiosurgery for managing refractory cancer-related bone pain.
  • Conducted as a retrospective palliative case series
  • Included selected patients with refractory metastatic bone pain
  • Evaluated short-term outcomes post-procedure for pain reduction
  • Patients experienced rapid pain reduction shortly after gamma knife radiosurgery
  • No immediate complications were reported after the procedure
  • Long-term safety and efficacy could not be conclusively determined due to limited follow-up

Abstract

In this small retrospective palliative case series, GKPR was associated with rapid short-term pain reduction in selected patients with refractory cancer-related bone pain without immediate procedure-related complications. Given the limited sample size, short follow-up duration inherent to the palliative setting and absence of systematic endocrine evaluation, conclusions regarding long term durability or safety cannot be drawn. Nonetheless, these observations suggest that GKPR may represent a feasible, minimally invasive, palliative option for carefully selected patients, warranting further prospective investigations.

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Cite This Study

Wong et al. (2026) studied this question.

synapsesocial.com/papers/69d893a86c1944d70ce049d2https://doi.org/10.1159/000551730
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