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April 10, 2026Small Methods

Programmable Dual‐Targeting Nano Bioconjugates: a Universal Bioconjugation Strategy to Enhance Single Molecule Proteomic Assays (Small Methods 7/2026)

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Authors

FFFahimeh FarokhinejadWAWill AndersonXNXueming Niu

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Overview

This research demonstrates programmable bioconjugates enhancing biomarker detection in proteomic assays, implying better diagnostics.

Key Points

  • The study aims to enhance single molecule proteomic assays using programmable dual-targeting nano-bioconjugates.
  • Developed bispecific antibody fragments on PEGylated nanoparticle clusters.
  • Utilized SERS-based biosensing for biomarker detection.
  • Explored the modularity and specificity of dual-targeting approach.
  • Achieved improved sensitivity in multiplexed biomarker detection.
  • Demonstrated successful dual recognition at the single-molecule level.
  • Showed broader applications for functional nanomaterial design.

Cite This Study

Farokhinejad et al. (2026) studied this question.

synapsesocial.com/papers/69d893c96c1944d70ce04bb8https://doi.org/10.1002/smtd.70581
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