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April 10, 2026Alzheimer s & Dementia2 citationsOpen Access

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

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MKMaria Kreger KarabovaWellcome Centre for Integrative NeuroimagingASAnna del Ser‐BadiaWellcome Centre for Integrative NeuroimagingAHAnne HedegaardWellcome Centre for Integrative Neuroimaging

Key Points

  • The research aims to investigate how human microglia respond to tau and the mechanisms involved in its spread.
  • Examined responses of human iPSC-derived microglia to tau
  • Analyzed tau uptake and secretion in microglial cells
  • Investigated the role of extracellular vesicles in tau propagation.
  • New insights into tau uptake mechanisms by microglia
  • Identification of seedable tau secretion pathways
  • Opportunities highlighted for limiting pathogenic tau spread.

Abstract

Our study reveals new insights into human microglial responses to tau, highlighting opportunities to limit pathogenic tau spread.

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Cite This Study

Karabova et al. (2026) studied this question.

synapsesocial.com/papers/69d893eb6c1944d70ce04d34https://doi.org/10.1002/alz.71337
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