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April 10, 2026Advanced Science0 citationsOpen Access

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

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LHLinwen HuangGuangzhou University of Chinese MedicineHTHuishi TanRELX Group (United States)SWSenhui WengGuangzhou University of Chinese Medicine

Key Points

  • This research investigates how gut lactate impacts Ruminococcus to improve Crohn's disease outcomes.
  • Examined the role of time-restricted feeding (TRF) on gut microbiota.
  • Analyzed the histone lactylation-SLC9A3 signaling pathway.
  • Observed the effects on inflammation and fibrosis in Crohn’s disease model.
  • TRF increased SCFA-producing Ruminococcus levels.
  • Histone lactylation was linked to improved gut barrier integrity.
  • Enhanced mitochondrial β-oxidation was noted in epithelial cells.

Abstract

Collectively, TRF enriches SCFA-producing Ruminococcus through a gut lactate-driven histone lactylation-SLC9A3 signaling axis, thereby alleviating inflammation and fibrosis in Crohn's disease under preventive conditions. Ruminococcus-derived SCFA further enhances epithelial mitochondrial β-oxidation and activates HIF-1α-dependent signaling pathways to strengthen the barrier integrity. This study provides a compelling mechanistic foundation for the clinical exploration of TRF as a therapeutic dietary strategy for patients with CD.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69d895046c1944d70ce05f2ehttps://doi.org/10.1002/advs.202518419
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