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April 10, 2026Animal Models and Experimental Medicine0 citationsOpen Access

Transcriptomic validation of a 7,12 Dimethylbenz(a)anthracene ( DMBA )‐induced leukemia rat model: Parallels with human leukemogenesis

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KAKhaldoon AlsammanOEOmar S. El‐Masry

Key Points

  • The research aims to validate a leukemia rat model induced by DMBA and compare its transcriptomic profile with that of human leukemia.
  • Utilized a DMBA-induced rat model to study leukemia.
  • Conducted transcriptomic analysis to identify oncogenic features.
  • Compared findings with human leukemia characteristics.
  • The rat model displayed a transcriptomic profile similar to that found in human leukemia.
  • Key oncogenic and prognostic features were identified in both the model and humans.
  • The findings support the model's use for preclinical studies in leukemogenesis.

Abstract

In conclusion, the DMBA-induced leukemia rat model exhibits a transcriptomic profile that closely mirrors key oncogenic and prognostic features of human leukemia. This model holds significant promise for preclinical studies targeting leukemogenesis and therapeutic intervention strategies.

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Cite This Study

Alsamman et al. (2026) studied this question.

synapsesocial.com/papers/69d895486c1944d70ce063cfhttps://doi.org/10.1002/ame2.70202
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