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April 10, 2026Current Medical IssuesOpen Access

Effectiveness of Short Versus Traditional Antibiotic Prophylaxis in Clean Surgeries: A Nonrandomized Observational Study

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Authors

DYDeepak Kumar YadavAJAnant Jain

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Overview

Nonrandomized observational study finds single-dose antibiotic prophylaxis prevents SSIs effectively in clean surgeries, suggesting cost and safety benefits.

Key Points

  • This study aims to compare the efficacy of short versus traditional antibiotic prophylaxis in preventing surgical site infections following clean surgeries.
  • Conducted a prospective non-randomized observational study over 18 months
  • Enrolled 384 patients undergoing elective clean surgeries
  • Assigned patients to single-dose prophylaxis or traditional prophylaxis
  • Measured outcomes included surgical site infections at 30 days, hospitalization duration, adverse events, and costs
  • SSI rates were similar between short (4.7%) and traditional (5.2%) prophylaxis groups
  • Short prophylaxis resulted in a shorter hospital stay (3.8 vs. 4.1 days)
  • Fewer antibiotic-related adverse events in the short group (2.1% vs. 8.3%)
  • Traditional regimen had higher overall antibiotic costs

Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/69d895d86c1944d70ce06e72https://doi.org/10.4103/cmi.cmi_205_25
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