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April 10, 2026Clinical Case Reports0 citationsOpen Access

Successful Interstitial HDR Brachytherapy for Nasal Skin SCC in Xeroderma Pigmentosum: An Eight‐Year Follow‐Up Case Report

PSPouya SaraeiAhvaz Jundishapur University of Medical SciencesVDVita DerakhshandehIran University of Medical SciencesABAli Bagheri

Key Points

  • To evaluate the effectiveness of high-dose-rate interstitial brachytherapy in treating cutaneous squamous cell carcinoma in patients with xeroderma pigmentosum.
  • Long-term follow-up of a patient with xeroderma pigmentosum and cutaneous squamous cell carcinoma
  • Treatment with high-dose-rate interstitial brachytherapy
  • Assessment of local control and cosmetic outcomes
  • Durable local control of squamous cell carcinoma was achieved
  • Acceptable cosmetic outcomes noted after treatment
  • Challenges the notion that radiotherapy is an absolute contraindication in xeroderma pigmentosum

Abstract

ABSTRACT High‐dose‐rate interstitial brachytherapy may provide durable local control with acceptable cosmetic outcomes in carefully selected patients with xeroderma pigmentosum and cutaneous squamous cell carcinoma. This long‐term follow‐up case questions the absolute contraindication of radiotherapy in XP and underscores the importance of individualized treatment planning based on underlying DNA repair mechanisms.

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Cite This Study

Saraei et al. (2026) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce07110https://doi.org/10.1002/ccr3.72516
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