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April 10, 2026Journal of Cosmetic Dermatology0 citationsOpen Access

Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler–Induced Skin Necrosis: A Prospective Clinical Case Series

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MOMacarena OlivaresUniversidade do Oeste PaulistaDADiego ArayaInstituto Chileno de Medicina ReproductivaEFEloisa ForeroInstituto Chileno de Medicina Reproductiva

Key Points

  • The aim is to evaluate the effectiveness and safety of the Advanced Regenerative Drainage and Immunomodulatory Protocol (ARDIP) for treating dermal filler-induced skin necrosis.
  • Prospective clinical case series design
  • Multimodal approach addressing vascular obstruction
  • Management of inflammatory responses
  • ARDIP demonstrated a safe application in clinical settings
  • Significant reduction in necrosis symptoms observed
  • Effective in restoring skin integrity in affected areas

Abstract

ARDIP appears to be a safe and effective multimodal strategy for the management of filler-induced skin necrosis, addressing both mechanical vascular obstruction and the associated inflammatory cascade.

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Cite This Study

Olivares et al. (2026) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce0723ahttps://doi.org/10.1111/jocd.70847
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