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April 10, 2026Diabetes Obesity and Metabolism0 citations

Pathway‐Specific Polygenic Risk Scores and Cardiorenal Complications in Asians With Type 2 Diabetes

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RGResham L GurungHZHuili ZhengJTJia Le Ivan Tan

Key Result

Pathway-specific polygenic risk scores were differentially associated with cardiorenal outcomes and related circulating proteins in multi-ethnic Asians with type 2 diabetes.

Key Points

  • The research aims to explore how specific genetic factors contribute to cardiorenal complications in Asians with type 2 diabetes.
  • Analyzed a multi-ethnic Asian population
  • Evaluated associations between polygenic risk scores and cardiorenal outcomes
  • Assessed the relationship with circulating proteins
  • Identified differential associations between genetic susceptibility and cardiorenal outcomes
  • Highlighted the relevance of specific biological pathways in diverse populations
  • Indicated the need for validation in independent cohorts

Structured PICO

Are pathway-specific polygenic risk scores associated with cardiorenal complications in Asians with Type 2 diabetes?

P
Population
Multi-ethnic Asian population with Type 2 Diabetes
I
Intervention
Pathway-specific polygenic risk scores
O
Outcome
Cardiorenal outcomes and related circulating proteins

Pathway-specific polygenic risk scores show differential associations with cardiorenal outcomes in Asian patients with type 2 diabetes, highlighting the potential relevance of biologically informed genetic pathways.

Limitations

  • Requires validation in independent cohorts

Abstract

In a multi-ethnic Asian population, pathway-specific genetic susceptibility was differentially associated with cardiorenal outcomes and related circulating proteins. These findings suggest the potential relevance of biologically informed genetic pathways in diverse populations and warrant validation in independent cohorts.

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Cite This Study

Gurung et al. (2026) studied this question. Pathway-specific polygenic risk scores were differentially associated with cardiorenal outcomes and related circulating proteins in multi-ethnic Asians with type 2 diabetes.

synapsesocial.com/papers/69d896676c1944d70ce07cb2https://doi.org/10.1111/dom.70741
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Also Consider

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  3. 3Cardiorenal Risk Profiles Among Data-Driven Type 2 Diabetes Sub-Phenotypes: A Post-Hoc Analysis of the China Health and Nutrition Survey2022 · 13 citations
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  5. 5Excess risk of hospitalisation for heart failure among people with type 2 diabetes2018 · 50 citations