PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 11, 2020Journal of Neuroinflammation72 citationsOpen Access

Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage

PPPengyu PanHZHengli ZhaoXZXuan Zhang

Key Points

Key points are not available for this paper at this time.

Abstract

This study demonstrated for the first time that CypA mediated the harmful effects of pericytes on BBB disruption after SAH, which potentially mediated by CD147/NF-κB/MMP9 signal, and junction protein degradation in the brain. By targeting CypA and pericytes, this study may provide new insights on the management of SAH patients.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Pan et al. (2020) studied this question.

synapsesocial.com/papers/69d8d0b013e0539d74bed955https://doi.org/10.1186/s12974-020-1699-6
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cyclosporine1989 · 1,373 citations
  2. 2Pericytes: Cell Biology and Pathology2001 · 450 citations
  3. 3The Novel Cyclophilin-Binding Drug Sanglifehrin A Specifically Affects Antigen Uptake Receptor Expression and Endocytic Capacity of Human Dendritic Cells2004 · 29 citations
  4. 4Cyclophilin A Is Secreted by a Vesicular Pathway in Vascular Smooth Muscle Cells2006 · 218 citations
  5. 5Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in Itk2004 · 222 citations