Is there a bidirectional association between depressive symptoms and incident type 2 diabetes?
There is a complex bidirectional relationship between depressive symptoms and type 2 diabetes, where the treatment status of diabetes influences the direction of its association with incident depression.
A modest association of baseline depressive symptoms with incident type 2 diabetes existed that was partially explained by lifestyle factors. Impaired fasting glucose and untreated type 2 diabetes were inversely associated with incident depressive symptoms, whereas treated type 2 diabetes showed a positive association with depressive symptoms. These associations were not substantively affected by adjustment for potential confounding or mediating factors.
Sherita Hill Golden (2008) studied this question.