Do postoperative NSAIDs increase the risk of anastomotic complications in patients undergoing nonelective colorectal resection?
Postoperative NSAID use is associated with an increased risk of anastomotic complications following nonelective colorectal resection.
Postoperative NSAIDs were associated with a significantly increased risk for anastomotic complications among patients undergoing nonelective colorectal resection. To determine the role of NSAIDs in colorectal surgery, future evaluations should consider specific formulations, the dose effect, mechanism, and other relevant outcome domains, including pain control, cardiac complications, and overall recovery.
Hakkarainen et al. (2015) studied this question.
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