Does postoperative use of non-steroidal anti-inflammatory drugs increase anastomotic leakage in patients after colorectal resection?
Postoperative use of diclofenac and COX-2 selective NSAIDs may increase the risk of anastomotic leakage after colorectal resection.
Diclofenac treatment could result in an increased proportion of patients with anastomotic leakage after colorectal surgery. Cyclo-oxygenase-2 selective NSAIDs should be used with caution after colorectal resections with primary anastomosis. Large scale, randomised controlled trials are urgently needed.
Klein et al. (2012) studied this question.