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December 22, 2006Hepatology1,264 citations

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

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SBSandrine BoyaultDRDavid S. RickmanARAurélien de Reyniès

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Abstract

These results have furthered our understanding of the genetic diversity of human HCC and have provided specific identifiers for classifying tumors. In addition, our classification has potential therapeutic implications because 50% of the tumors were related to WNT or AKT pathway activation, which potentially could be targeted by specific inhibiting therapies.

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Boyault et al. (2006) studied this question.

synapsesocial.com/papers/69d8f994d2f7327e70ae4b3ahttps://doi.org/10.1002/hep.21467
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