June 3, 1983Science655 citations
DNA Methylation Decreases in Aging But Not in Immortal Cells
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Abstract
When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.
Cite This Study
Wilson et al. (1983) studied this question.