The HIF-1α/JMJD1A signaling pathway regulates oxidative stress and inflammation in diabetic vascular injury models, presenting a potential mechanistic target.
These findings provide novel evidence that the HIF-1α/JMJD1A signaling pathway is involved in inflammation and oxidative stress in HUVECs induced by high glucose and hypoxia. Also, this pathway might act as a novel regulator of oxidative stress and inflammatory-related events in response to diabetic vascular injury and thus contribute to the pathological progression of diabetes and vascular disease.
Zhao et al. (2021) studied this question.