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November 5, 2009BMC Medicine183 citationsOpen Access

STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect

SPSean P. PitrodaBWBassam T. WakimRSRavi F. Sood

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Abstract

Our results identify a previously uncharacterized function of STAT1 in tumours: expressional regulation of genes encoding proteins involved in glycolysis, the citrate cycle and mitochondrial oxidative phosphorylation, with predominant regulation of glycolytic genes. STAT1-dependent expressional regulation of glycolysis suggests a potential role for STAT1 as a transcriptional modulator of genes responsible for the Warburg effect.

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Pitroda et al. (2009) studied this question.

synapsesocial.com/papers/69d94df18988aeabbe684c58https://doi.org/10.1186/1741-7015-7-68
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