PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
December 4, 1991JAMA871 citations

Relationship Between Resistance to Insulin-Mediated Glucose Uptake, Urinary Uric Acid Clearance, and Plasma Uric Acid Concentration

View Full Paper
FFFrancesco Facchini

Key Points

  • This research investigates the link between insulin resistance and uric acid levels in the body, focusing on kidney function.
  • Evaluated urinary uric acid clearance in normal volunteers as insulin resistance increased.
  • Measured serum uric acid concentrations to assess changes due to insulin resistance.
  • As insulin resistance increased, urinary uric acid clearance decreased, leading to higher serum uric acid levels.

Abstract

Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Thus, it appears that modulation of serum uric concentration by insulin resistance is exerted at the level of the kidney.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Francesco Facchini (1991) studied this question.

synapsesocial.com/papers/69d953e1f20ef2633068488chttps://doi.org/10.1001/jama.1991.03470210076036
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Some Factors Related to Coronary Heart Disease Incidence in Honolulu Japanese Men: The Honolulu Heart Study1975 · 81 citations
  2. 2Uric acid: a risk factor for coronary heart disease?1979 · 133 citations
  3. 3Immunoassay of insulin with insulin-antibody precipitate1963 · 2,657 citations
  4. 4Gout and hyperuricemia1976 · 121 citations
  5. 5A New and Rapid Method for the Determination of Glucose by Measurement of Rate of Oxygen Consumption1968 · 749 citations