Does major bleeding after percutaneous coronary intervention increase the risk of subsequent mortality and MACEs?
Major bleeding after PCI is strongly associated with increased subsequent mortality and MACE, though the magnitude of risk varies significantly based on the bleeding definition used.
Major bleeding after PCI is independently associated with a threefold increase in mortality and MACEs outcomes. Different contemporary bleeding definitions have differential impacts on mortality outcomes, with 1.5-6.7-fold increases in mortality observed depending on the definition of major bleeding used.
Kwok et al. (2014) studied this question.