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June 22, 1974BMJOpen Access

Controlled Sedation with Alphaxalone-Alphadolone

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Population

30 patients in an intensive therapy unit

Design

Case_series

Follow-up

up to 20 days

Authors

MRMichael A. E. RamsayTST.M. SavegeBSB. R. Simpson

Discussion

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Overview

Hypothesis-generating for alphaxalone-alphadolone in ICU sedation; controlled trials needed before any practice consideration.

Structured PICO

P
Population
30 patients in an intensive therapy unit
I
Intervention
Alphaxalone-alphadolone diluted and administered as a controlled infusion for periods up to 20 days
O
Outcome
Satisfactory sedation

Alphaxalone-alphadolone controlled infusion provides effective, rapidly adjustable sedation without tachyphylaxis or delayed recovery in intensive care patients.

Cite This Study

Ramsay et al. (1974) studied this question.

synapsesocial.com/papers/69d990c92a25b240b7a3cea0https://doi.org/10.1136/bmj.2.5920.656
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