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June 3, 2022Journal of Clinical Oncology72 citationsOpen Access

TP53 Sequencing and p53 Immunohistochemistry Predict Outcomes When Bevacizumab Is Added to Frontline Chemotherapy in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study

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KTKristina W. ThielEDEric J. DevorVFVirginia L. Filiaci

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Abstract

IHC for p53 alone or when integrated with sequencing for TP53 identifies a specific, high-risk tumor genotype/phenotype for which bevacizumab is particularly beneficial in improving outcomes when combined with chemotherapy.

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Thiel et al. (2022) studied this question.

synapsesocial.com/papers/69d9b7825e5bcb4e3b837bb7https://doi.org/10.1200/jco.21.02506
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