Pinynditerpene A (1), an unprecedented abietane diterpenoid featuring a unique 6/5/6/5-fused indeno7,1-bcfuran skeleton with 5 consecutive chiral centers, was isolated from Pinus yunnanensis resins. Its structure was elucidated by spectroscopic, computational, and crystallographic methods. 1 was found to be able to alleviate inflammation associated depression-like behaviors in mice, exerting its significance in mood disorders.
Liu et al. (2026) studied this question.