September 5, 2014Circulation Heart Failure128 citations
The Hemodynamic Basis of Exercise Intolerance in Tricuspid Regurgitation
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Structured PICO
P
Population
People with severe tricuspid regurgitation (TR)
Exercise intolerance in severe tricuspid regurgitation is hemodynamically driven by low cardiac output reserve and elevated bilateral filling pressures due to ventricular interaction.
Abstract
Impaired exercise capacity in people with severe TR is related to low cardiac output reserve relative to metabolic needs, coupled with elevated systemic and pulmonary venous pressures. Left heart pressures are elevated with exercise in subjects with TR, despite low LV preload, secondary to enhanced ventricular interaction.
Cite This Study
Andersen et al. (2014) studied this question.