This preclinical study suggests that catecholamine-induced lipotoxicity, driven by ApoB inhibition, is a key mechanism in the pathogenesis of stress-induced cardiomyopathy.
The present study demonstrates that lipotoxicity is closely associated with catecholamine-induced myocardial dysfunction, including neurogenic stunning, metabolic stunning, and electrophysiological stunning. Cardiac lipotoxicity may originate from direct inhibition of myocardial ApoB lipoprotein and subsequent decreased lipid export, caused by supraphysiological levels of catecholamines.
Shao et al. (2012) studied this question.