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February 1, 1999Angewandte Chemie International Edition321 citations

Sharpless Asymmetric Aminohydroxylation: Scope, Limitations, and Use in Synthesis

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POPeter O’Brien

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Abstract

As a valuable methodology for organic synthesis, asymmetric aminohydroxylation (AA)-the catalytic and asymmetric conversion of alkenes into enantiomerically enriched N-protected amino alcohols-has become established in a remarkably short period of time. Examples of the types of products that can be synthesized easily on a reasonably large scale and in enantiomerically pure form are shown in the picture.

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Peter O’Brien (1999) studied this question.

synapsesocial.com/papers/69da262b8988aeabbe686a71https://doi.org/10.1002/(sici)1521-3773(19990201)38:3<326::aid-anie326>3.0.co;2-t
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