Arginine mutations in S4 segments account for 90% of hypokalemic periodic paralysis cases, supporting the gating pore cation leak hypothesis.
All mutations affected arginine residues, consistent with the gating pore cation leak hypothesis of hypokalemic periodic paralysis. Arginine mutations in S4 segments underlie 90% of hypokalemic periodic paralysis cases.
Matthews et al. (2008) studied this question.