Does blocking IL-18 prevent inflammatory responses and cardiac injuries upon acute β-adrenergic insult?
Early blockade of IL-18 prevents cardiac inflammation and pathological remodeling triggered by acute β-adrenergic over-activation.
Inflammasome-dependent activation of IL-18 within the myocardium upon acute β-AR over-activation triggers cytokine cascades, macrophage infiltration and pathological cardiac remodelling. Blocking IL-18 at the early stage of β-AR insult can successfully prevent inflammatory responses and cardiac injuries.
Xiao et al. (2017) studied this question.