PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 25, 2003Genes to Cells818 citations

Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

View Full Paper
KIKen ItohNWNobunao WakabayashiYKYasutake Katoh

Key Points

Key points are not available for this paper at this time.

Abstract

Our results highlight the fact that Nrf2 protein turnover is regulated by Keap1 mediated subcellular compartmentalization.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Itoh et al. (2003) studied this question.

synapsesocial.com/papers/69dabf3faae38ff6ad8365d2https://doi.org/10.1046/j.1365-2443.2003.00640.x
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium2003 · 463 citations
  2. 2Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition.1984 · 544 citations
  3. 3Synthetic Signals for Ubiquitin-Dependent Proteolysis1995 · 65 citations
  4. 4Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription2001 · 520 citations
  5. 5Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz1995 · 184 citations